Tofacitinib is an immunosuppressant that depresses the immune system. It belongs to the inhibitors of janus kinases.

Release form: film-coated tablets, 5 mg and 10 mg.

Indications

Tofacitinib is used to treat various diseases.:

• Rheumatoid arthritis: for adults with moderate to severe arthritis who do not respond to standard medications.
• Psoriatic arthritis: for patients with active arthritis who do not respond to conventional therapy. Ankylosing spondylitis**: for adults with spinal inflammation who do not respond to standard treatment.
• Plaque psoriasis: for adults with severe psoriasis when systemic medications or phototherapy are indicated.
• Ulcerative colitis: for the induction and maintenance of remission in adults with severe colitis who do not respond to glucocorticoids or other medications.
• Juvenile idiopathic arthritis: for children over 2 years of age with active polyarticular arthritis.

Contraindications

Do not apply when:

• Allergies to tofacitinib.
• Severe liver diseases.
• Hepatitis B and/or C viruses.
• Severe or active infections.
• Lactose intolerance or lactase deficiency.
• Pregnancy (safety has not been studied).
• Breastfeeding.
• Under the age of 18.

Dosage and application

The drug is taken orally, regardless of food. The dosage depends on the disease:

• Rheumatoid, psoriatic and ankylosing arthritis: 5 mg twice daily. The doctor can change the dosage.
• Plaque psoriasis: 10 mg twice daily.
• Ulcerative colitis: 10 mg twice daily for 8 weeks, followed by dose adjustment.

The duration of treatment is determined by the doctor. Do not stop taking it without consultation.

Side effects

Possible side effects:

• Fever, chills, sweating.
• Stomach or abdominal pain.
• Difficulty breathing or swallowing.
• Dizziness.
• Swelling of the face.