Osimertinib is an antitumor drug that belongs to the group of protein kinase inhibitors. It is available in the form of film-coated tablets.

How does the drug work?

Osimertinib blocks the work of a special enzyme, tyrosine kinase of the epidermal growth factor receptor (EGFR). This helps slow down or stop tumor growth and the spread of cancer cells, especially if an EGFR gene mutation is detected in the tumor cells (for example, deletions in exon 19 or L858R substitutions in exon 21). The drug may also reduce the risk of recurrence after tumor removal.

When is it used?

Osimertinib is prescribed for adult patients over 18 years of age:

• After surgery to prevent tumor re-growth in non-small cell lung cancer, if an EGFR mutation is detected in the cells.
• As the primary treatment for advanced or metastatic non-small cell lung cancer with an EGFR mutation.
• For the treatment of locally advanced or metastatic non-small cell carcinoma with the T790M mutation in the EGFR gene.

Who can't take it?

The drug is contraindicated in:

• Allergies to osimertinib or its components.
• Pregnancy and lactation.
• Severe renal or liver dysfunction.
• Under the age of 18.

It is used with caution for lung diseases, prolongation of the QTc interval and simultaneous administration with certain medications.

How to take it?

It is usually recommended to take 80 mg once a day. As prescribed by a doctor, the dose can be reduced to 40 mg. Tablets are swallowed whole, washed down with water, at the same time, regardless of food.

The doctor determines the dosage and duration of treatment based on the patient's condition. It is forbidden to change the reception schedule yourself.

Side effects

Possible side effects include:

• Skin reactions: rash, dryness, itching.
• Digestive problems: diarrhea, stomatitis.
• Respiratory: pneumonitis-like reactions (in rare cases).
• Cardiovascular: prolongation of the QT interval, decreased heart function.
• Hematopoiesis: decreased platelet and neutrophil levels.
• General: weakness, swelling.