Norfloxacin 400 mg is an antimicrobial agent in the form of film-coated tablets. There are 10 tablets in each package. The drug inhibits bacterial DNA gyrase, exerting a bactericidal effect.

Indications

Norfloxacin is used to treat infectious and inflammatory diseases caused by sensitive microorganisms. These include:

• Infections of the urinary tract (cystitis, pyelonephritis, pyelitis).
• Chronic bacterial prostatitis.
• Uncomplicated gonorrhea.
• Bacterial infections of the gastrointestinal tract.
• Prevention of recurrent infections of the urinary tract, bacterial infections in patients with granulocytopenia, and traveler's diarrhea.

Method of administration and dosage

The drug is taken on an empty stomach, 1 hour before or 2 hours after a meal, with water. The dosage and duration of treatment depend on the disease:

• Complicated urinary tract infections: 400 mg twice a day, 10-21 days.
• Chronic bacterial prostatitis: 400 mg twice a day, 4 weeks or longer.
• Uncomplicated urinary tract infections in men: 400 mg twice a day, 7-14 days.
• Acute uncomplicated cystitis in women: 400 mg twice a day, 3-7 days.

In case of renal insufficiency (creatinine clearance less than 30 ml/min), the dose should be halved or taken once a day.

Special instructions

• During long-term treatment, urine analysis for crystalluria is monitored.
• Do not exceed the recommended daily dose, and drink enough fluids.
• Norfloxacin should be taken 2 hours before or after taking medications containing iron, magnesium, calcium, or sucralfate.

Contraindications

• Pregnancy and lactation.
• Age under 15.
• Glucose-6-phosphate dehydrogenase deficiency.
• Allergy to norfloxacin and other quinolones.

Side effects

• Digestive system: nausea, heartburn, diarrhea, abdominal pain.
• CNS: headache, dizziness, fatigue, insomnia, irritability, anxiety.
• Allergic reactions: rash, itching, Quincke's edema.
• Urinary system: interstitial nephritis.

Important

• Follow national recommendations on antibiotics.
• Consider the sensitivity of pathogens in a particular country.