Imatinib is an anti-cancer drug that blocks the enzymes responsible for cell growth and division. It is available in tablet form (100 and 400 mg) and capsule form (50 and 100 mg).

How it works

The drug inhibits the activity of enzymes known as tyrosine kinases, which play a crucial role in cell proliferation.

When it is used

Imatinib is used to treat various types of cancer:

• chronic myeloid leukemia;
• acute lymphoblastic leukemia;
• myelodysplastic and myeloproliferative diseases;
• eosinophilic leukemia;
• mastocytosis;
• gastrointestinal stromal tumors (cancer of the stomach and intestines);
• dermatofibrosarcoma (a rare skin disease).

Important

The drug is available only with a prescription. The dosage and duration of treatment are determined by the doctor, taking into account the patient's diagnosis, test results, and individual characteristics.

Who should not take the medication

The medication is contraindicated in the following cases:

• if the patient is allergic to imatinib or its components;
• in children under 1 year of age with acute lymphoblastic leukemia;
• in children under 2 years of age with chronic myeloid leukemia;
• in pregnant and lactating women.

It is used with caution in patients with severe liver and kidney failure, heart disease, and those on hemodialysis.

How to take

The tablets and capsules are taken with food, with water. The daily dose of 400-600 mg is taken in one dose, and 800 mg is divided into two doses, taken in the morning and evening.

Features of taking

• In case of chronic myeloid leukemia, the dose is selected depending on the stage of the disease: 400 mg in the chronic phase, 600 mg in the acute phase.
• Patients with liver disorders are prescribed a minimum dose of 400 mg per day.
• Patients with kidney problems or those undergoing hemodialysis should start with a minimum dose and closely monitor their condition.

If serious side effects occur, treatment should be temporarily suspended and then resumed at a reduced dose.

Possible side effects**

• Blood: decrease in neutrophil and platelet levels, anemia.
• Digestive system: loss of appetite, nausea, vomiting, diarrhea, abdominal pain, bloating.
• Nervous system: headache, dizziness, impaired taste, insomnia.
• Vision: conjunctivitis, lacrimation, visual impairment.
• Heart and blood vessels: heart failure, pulmonary edema, increased or decreased blood pressure. Musculoskeletal system*: muscle spasms, joint pain.
• Urinary system: kidney failure, kidney pain.